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Journal : MNJ (Malang Neurology Journal)

PROFILE OF SUBJECTIVE SLEEP DISTURBANCE IN PATIENT WITH ANTIEPILEPTIC DRUGS Zahra, Farah Az; Islamiyah, Wardah Rahmatul; Budiono, Budiono
Malang Neurology Journal Vol 5, No 2 (2019): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.02.2

Abstract

Background: Epilepsy and sleep are well recognized for having bidirectional influences upon one another. The effects of antiepileptic drugs (AEDs) on sleep are of particular concern.
Objective: The objective of this study is to know the profile of AEDs effect in patient’s sleep cycle. Methods: This analytical observational study observed total sleep time, sleep onset latency, sleep efficiency, daytime sleepiness, and insomnia in epileptic patient with AEDs of Neurology Clinic Airlangga University Hospital during May-September 2016. A cross sectional study was done by questionnaire and interview directly to the epileptic patients. Data collected was being analyzed analytically.Results: This research was conducted among 27 patients with epilepsy based on inclusion and exclusion criteria. Sleep disturbances that had been found in patients with phenytoin are prolong sleep onset latency (11.11%), decreased sleep efficiency (11.11%), and excessive daytime sleepiness (66.67%). Sleep disturbances that had been found in patients with valproate are decreased total sleep time (33.33%), prolong sleep onset latency (11.11%), decreased sleep efficiency (11.11%), excessive daytime sleepiness (66.67%), and insomnia (11.11%). Sleep disturbances that had been found in patients with carbamazepine are decreased total sleep time (44.44%), prolong sleep onset latency (33.33%), decreased sleep efficiency (22.22%), excessive daytime sleepiness (77.78%), and insomnia (11.11%).Conclusion: In conclusion, this study shows that epileptic patients who consumed AEDs regularly may have sleep disturbance that vary based on the type of AEDs, patients with carbamazepine may have bigger sleep disturbance than with phenytoin and valproate. It is necessary to give information and education to the epileptic patients who consumed AEDs regularly so that they will become aware of the sign of sleep disturbance.
Co-Authors Abd. Syakur Agus Frianto Agus Tinus Aindrianingsih, Aindrianingsih Ainistikmalia, Nurin Alif Tiwi Estriyanti Alpha Fardah Athiyyah Amalia, Firdha Anang Kistyanto Andre Dwijanto Witjaksono Anisya Fitri Aprilia Wulan Asri Wijayanti AYU WULANDARI Badu’l Mat Saleh Baksono Winardi Bayu Kharisma Brahmana Askandar Tjokroprawiro Candra Rahma Wijaya Putra Dachlan, Yoes P Dewi Ayu Lestari Dewi, Gita Kusuma Diyah Fatmasari Diyah Putri Permata Djoko Sutikno Dominicus Husada Dwi Puji Rahayu Rahayu Endang Susilaningsih ERI PERDANA USHAN Faizah Yunianti Fitriah Fitriah Fitriah Fitriah Hafid Kholidi Hadi Haruki Uemura I Gusti Made Reza Gunadi Ranu I Gusti Made Reza Gunadi Ranuh Ika Rahmania Indrian Supheni Islamiyah, Wardah Rahmatul IWayan Sarjana Januardi, Dicky Jayanti, Lira Wiet Jun Surjanti Khoirunnisa, Nabila Farah Liesnaningsih Liesnaningsih M Y. Probohoesodo Muhammad Faizi Mustayah ., Mustayah Mustayah Mustayah Ngestreini, Rahmadani Nadya Nikie Astorina Yunita Dewanti Octavia, Dini Hariani Pertami, Sumirah Budi Pertami, Sumirah Budi Rachman Iswanto Raden Bagus Yanuar Renaldy Rahayu, Dian Yuniar Syanti Ratna Feti Wulandari Risky Dwiprabowo Ristya Sylva Imannia Rohmat Taufiq Rose Fitria Lutfiana ROSSYANTI, LYNDA Shalima, Irsyadi Sidarti Soehita Siswanto Darmadi Sita Hendrakusuma Samsu Siti Fatimah Soenaryo Siti Wahyu Wulandari Slamet Wahyudi Soraya Salle Pasulu Sriwijayanti Sulistyawati Sugeng Riyanto Sugeng Riyanto Sugeng Sutiarso Sukmawati Basuki Sulistyawati, Sriwijayanti Suwarsono Suwarsono Syarifuddin Dahlan Tony Seno Aji Uemura, Haruki Umu Nur Latifah Vide Bahtera Dinastiti Vinzy Yulina Widiana, Putri Wina Aprilia Purnamasari Wolayan, Grahana Ade Candra Yoes P Dachlan Yuyun Isbanah Zahra, Farah Az Zukhaila Salma